MaghrebDataLibMedV1, Main, Exploration, bibRecord, 000258

Genetic Distribution of the LTA +252 A>G and TNFA -308 G > A Polymorphisms in the Moroccan Population.

Identifieur interne : 000258 ( Main/Exploration ); précédent : 000257; suivant : 000259

Genetic Distribution of the LTA +252 A>G and TNFA -308 G > A Polymorphisms in the Moroccan Population.

Auteurs : Fatima Zahra Aznag [Maroc] ; Mohamed Taha Moutaoufik [Canada] ; Amal Korrida [Maroc] ; El Hassan Izaabel [Maroc]

Source :

Genetic testing and molecular biomarkers [ 1945-0257 ] ; 2019.

RBID : pubmed:31738572

Descripteurs français

KwdFr :
- Adulte (MeSH), Allèles (MeSH), Cytokines (génétique), Déséquilibre de liaison (génétique), Facteur de nécrose tumorale alpha (génétique), Facteur de nécrose tumorale alpha (métabolisme), Facteur de nécrose tumorale alpha (sang), Femelle (MeSH), Fréquence d'allèle (génétique), Génotype (MeSH), Humains (MeSH), Lymphotoxine alpha (génétique), Lymphotoxine alpha (métabolisme), Lymphotoxine alpha (sang), Maroc (épidémiologie), Mâle (MeSH), Polymorphisme de nucléotide simple (génétique), Prédisposition génétique à une maladie (MeSH), Études cas-témoins (MeSH).
MESH :
- génétique : Cytokines, Déséquilibre de liaison, Facteur de nécrose tumorale alpha, Fréquence d'allèle, Lymphotoxine alpha, Polymorphisme de nucléotide simple.
- métabolisme : Facteur de nécrose tumorale alpha, Lymphotoxine alpha.
- sang : Facteur de nécrose tumorale alpha, Lymphotoxine alpha.
- épidémiologie : Maroc.
- Adulte, Allèles, Femelle, Génotype, Humains, Mâle, Prédisposition génétique à une maladie, Études cas-témoins.
Wicri :
- geographic : Maroc.

English descriptors

KwdEn :
- Adult (MeSH), Alleles (MeSH), Case-Control Studies (MeSH), Cytokines (genetics), Female (MeSH), Gene Frequency (genetics), Genetic Predisposition to Disease (MeSH), Genotype (MeSH), Humans (MeSH), Linkage Disequilibrium (genetics), Lymphotoxin-alpha (blood), Lymphotoxin-alpha (genetics), Lymphotoxin-alpha (metabolism), Male (MeSH), Morocco (epidemiology), Polymorphism, Single Nucleotide (genetics), Tumor Necrosis Factor-alpha (blood), Tumor Necrosis Factor-alpha (genetics), Tumor Necrosis Factor-alpha (metabolism).
MESH :
- chemical , blood : Lymphotoxin-alpha, Tumor Necrosis Factor-alpha.
- chemical , genetics : Cytokines, Lymphotoxin-alpha, Tumor Necrosis Factor-alpha.
- geographic , epidemiology : Morocco.
- genetics : Gene Frequency, Linkage Disequilibrium, Polymorphism, Single Nucleotide.
- chemical , metabolism : Lymphotoxin-alpha, Tumor Necrosis Factor-alpha.
- Adult, Alleles, Case-Control Studies, Female, Genetic Predisposition to Disease, Genotype, Humans, Male.

Abstract

Introduction: The LTA and TNFA genes encode key proinflammatory cytokines with diverse activities in the immune responses. Single nucleotide polymorphisms (SNPs) in the LTA rs909253 (+252 A > G) and TNFA rs1800629 (-308 G > A) genes have been associated with susceptibility to many complex diseases. The aim of this study was to assess the frequency for these two key polymorphisms in the Moroccan population. Materials and Methods: A total of 338 unrelated healthy Moroccan subjects were genotyped for the two alleles using a restriction fragment length polymorphism-polymerase chain reaction method. Results: The LTA (+252 A > G) and TNFA (-308 G > A) were the most common alleles with 67.9% and 74.8% frequencies, respectively. In addition to the linkage disequilibrium between the two SNPs, significant differences in allele frequencies were observed in Moroccan population compared with Mediterraneans, Europeans, Africans, South Americans, and Asians (p < 0.05). Finally, genetic proximities between Moroccan, European, and West African populations were found by means of the principal component analysis. Conclusion: The LTA +252 A>G and TNFA -308 G > A polymorphisms among Moroccan population follow the patterns commonly encountered in other Mediterranean, European, and African populations. The result of this study could contribute in developing a genetic database on the healthy Moroccan population.

DOI: 10.1089/gtmb.2019.0116
PubMed: 31738572

Affiliations:

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 +252 A>G and <i>TNFA</i>
 -308 G > A Polymorphisms in the Moroccan Population.</title>
<author><name sortKey="Aznag, Fatima Zahra" sort="Aznag, Fatima Zahra" uniqKey="Aznag F" first="Fatima Zahra" last="Aznag">Fatima Zahra Aznag</name>
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 +252 A>G and <i>TNFA</i>
 -308 G > A Polymorphisms in the Moroccan Population.</title>
<author><name sortKey="Aznag, Fatima Zahra" sort="Aznag, Fatima Zahra" uniqKey="Aznag F" first="Fatima Zahra" last="Aznag">Fatima Zahra Aznag</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratory of Cellular Biology and Molecular Genetics, Faculty of Sciences, Ibn Zohr University, Agadir, Morocco.</nlm:affiliation>
<country xml:lang="fr">Maroc</country>
<wicri:regionArea>Laboratory of Cellular Biology and Molecular Genetics, Faculty of Sciences, Ibn Zohr University, Agadir</wicri:regionArea>
<wicri:noRegion>Agadir</wicri:noRegion>
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<author><name sortKey="Moutaoufik, Mohamed Taha" sort="Moutaoufik, Mohamed Taha" uniqKey="Moutaoufik M" first="Mohamed Taha" last="Moutaoufik">Mohamed Taha Moutaoufik</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Biochemistry, University of Regina, Regina, SK, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Biochemistry, University of Regina, Regina, SK</wicri:regionArea>
<orgName type="university">Université de Regina</orgName>
<placeName><settlement type="city">Regina</settlement>
<region type="state">Saskatchewan</region>
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</affiliation>
</author>
<author><name sortKey="Korrida, Amal" sort="Korrida, Amal" uniqKey="Korrida A" first="Amal" last="Korrida">Amal Korrida</name>
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<wicri:noRegion>Agadir</wicri:noRegion>
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<wicri:noRegion>Agadir</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Izaabel, El Hassan" sort="Izaabel, El Hassan" uniqKey="Izaabel E" first="El Hassan" last="Izaabel">El Hassan Izaabel</name>
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<country xml:lang="fr">Maroc</country>
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<series><title level="j">Genetic testing and molecular biomarkers</title>
<idno type="eISSN">1945-0257</idno>
<imprint><date when="2019" type="published">2019</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term>
<term>Alleles (MeSH)</term>
<term>Case-Control Studies (MeSH)</term>
<term>Cytokines (genetics)</term>
<term>Female (MeSH)</term>
<term>Gene Frequency (genetics)</term>
<term>Genetic Predisposition to Disease (MeSH)</term>
<term>Genotype (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Linkage Disequilibrium (genetics)</term>
<term>Lymphotoxin-alpha (blood)</term>
<term>Lymphotoxin-alpha (genetics)</term>
<term>Lymphotoxin-alpha (metabolism)</term>
<term>Male (MeSH)</term>
<term>Morocco (epidemiology)</term>
<term>Polymorphism, Single Nucleotide (genetics)</term>
<term>Tumor Necrosis Factor-alpha (blood)</term>
<term>Tumor Necrosis Factor-alpha (genetics)</term>
<term>Tumor Necrosis Factor-alpha (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term>
<term>Allèles (MeSH)</term>
<term>Cytokines (génétique)</term>
<term>Déséquilibre de liaison (génétique)</term>
<term>Facteur de nécrose tumorale alpha (génétique)</term>
<term>Facteur de nécrose tumorale alpha (métabolisme)</term>
<term>Facteur de nécrose tumorale alpha (sang)</term>
<term>Femelle (MeSH)</term>
<term>Fréquence d'allèle (génétique)</term>
<term>Génotype (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Lymphotoxine alpha (génétique)</term>
<term>Lymphotoxine alpha (métabolisme)</term>
<term>Lymphotoxine alpha (sang)</term>
<term>Maroc (épidémiologie)</term>
<term>Mâle (MeSH)</term>
<term>Polymorphisme de nucléotide simple (génétique)</term>
<term>Prédisposition génétique à une maladie (MeSH)</term>
<term>Études cas-témoins (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Lymphotoxin-alpha</term>
<term>Tumor Necrosis Factor-alpha</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Cytokines</term>
<term>Lymphotoxin-alpha</term>
<term>Tumor Necrosis Factor-alpha</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Morocco</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Gene Frequency</term>
<term>Linkage Disequilibrium</term>
<term>Polymorphism, Single Nucleotide</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Cytokines</term>
<term>Déséquilibre de liaison</term>
<term>Facteur de nécrose tumorale alpha</term>
<term>Fréquence d'allèle</term>
<term>Lymphotoxine alpha</term>
<term>Polymorphisme de nucléotide simple</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Lymphotoxin-alpha</term>
<term>Tumor Necrosis Factor-alpha</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteur de nécrose tumorale alpha</term>
<term>Lymphotoxine alpha</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Facteur de nécrose tumorale alpha</term>
<term>Lymphotoxine alpha</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Maroc</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Alleles</term>
<term>Case-Control Studies</term>
<term>Female</term>
<term>Genetic Predisposition to Disease</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Allèles</term>
<term>Femelle</term>
<term>Génotype</term>
<term>Humains</term>
<term>Mâle</term>
<term>Prédisposition génétique à une maladie</term>
<term>Études cas-témoins</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Maroc</term>
</keywords>
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<front><div type="abstract" xml:lang="en"><b><i>Introduction:</i>
</b>
 The <i>LTA</i>
 and <i>TNFA</i>
 genes encode key proinflammatory cytokines with diverse activities in the immune responses. Single nucleotide polymorphisms (SNPs) in the <i>LTA</i>
 rs909253 (+252 A > G) and <i>TNFA</i>
 rs1800629 (-308 G > A) genes have been associated with susceptibility to many complex diseases. The aim of this study was to assess the frequency for these two key polymorphisms in the Moroccan population. <b><i>Materials and Methods:</i>
</b>
 A total of 338 unrelated healthy Moroccan subjects were genotyped for the two alleles using a restriction fragment length polymorphism-polymerase chain reaction method. <b><i>Results:</i>
</b>
 The <i>LTA</i>
 (+252 A > G) and <i>TNFA</i>
 (-308 G > A) were the most common alleles with 67.9% and 74.8% frequencies, respectively. In addition to the linkage disequilibrium between the two SNPs, significant differences in allele frequencies were observed in Moroccan population compared with Mediterraneans, Europeans, Africans, South Americans, and Asians (<i>p</i>
 < 0.05). Finally, genetic proximities between Moroccan, European, and West African populations were found by means of the principal component analysis. <b><i>Conclusion:</i>
</b>
 The <i>LTA</i>
 +252 A>G and <i>TNFA</i>
 -308 G > A polymorphisms among Moroccan population follow the patterns commonly encountered in other Mediterranean, European, and African populations. The result of this study could contribute in developing a genetic database on the healthy Moroccan population.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31738572</PMID>
<DateCompleted><Year>2020</Year>
<Month>04</Month>
<Day>13</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>04</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1945-0257</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>23</Volume>
<Issue>12</Issue>
<PubDate><Year>2019</Year>
<Month>Dec</Month>
</PubDate>
</JournalIssue>
<Title>Genetic testing and molecular biomarkers</Title>
<ISOAbbreviation>Genet Test Mol Biomarkers</ISOAbbreviation>
</Journal>
<ArticleTitle>Genetic Distribution of the <i>LTA</i>
 +252 A>G and <i>TNFA</i>
 -308 G > A Polymorphisms in the Moroccan Population.</ArticleTitle>
<Pagination><MedlinePgn>871-876</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1089/gtmb.2019.0116</ELocationID>
<Abstract><AbstractText><b><i>Introduction:</i>
</b>
 The <i>LTA</i>
 and <i>TNFA</i>
 genes encode key proinflammatory cytokines with diverse activities in the immune responses. Single nucleotide polymorphisms (SNPs) in the <i>LTA</i>
 rs909253 (+252 A > G) and <i>TNFA</i>
 rs1800629 (-308 G > A) genes have been associated with susceptibility to many complex diseases. The aim of this study was to assess the frequency for these two key polymorphisms in the Moroccan population. <b><i>Materials and Methods:</i>
</b>
 A total of 338 unrelated healthy Moroccan subjects were genotyped for the two alleles using a restriction fragment length polymorphism-polymerase chain reaction method. <b><i>Results:</i>
</b>
 The <i>LTA</i>
 (+252 A > G) and <i>TNFA</i>
 (-308 G > A) were the most common alleles with 67.9% and 74.8% frequencies, respectively. In addition to the linkage disequilibrium between the two SNPs, significant differences in allele frequencies were observed in Moroccan population compared with Mediterraneans, Europeans, Africans, South Americans, and Asians (<i>p</i>
 < 0.05). Finally, genetic proximities between Moroccan, European, and West African populations were found by means of the principal component analysis. <b><i>Conclusion:</i>
</b>
 The <i>LTA</i>
 +252 A>G and <i>TNFA</i>
 -308 G > A polymorphisms among Moroccan population follow the patterns commonly encountered in other Mediterranean, European, and African populations. The result of this study could contribute in developing a genetic database on the healthy Moroccan population.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Aznag</LastName>
<ForeName>Fatima Zahra</ForeName>
<Initials>FZ</Initials>
<AffiliationInfo><Affiliation>Laboratory of Cellular Biology and Molecular Genetics, Faculty of Sciences, Ibn Zohr University, Agadir, Morocco.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Moutaoufik</LastName>
<ForeName>Mohamed Taha</ForeName>
<Initials>MT</Initials>
<AffiliationInfo><Affiliation>Department of Biochemistry, University of Regina, Regina, SK, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Korrida</LastName>
<ForeName>Amal</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Laboratory of Cellular Biology and Molecular Genetics, Faculty of Sciences, Ibn Zohr University, Agadir, Morocco.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Higher Institute of Nursing Professions and Health Techniques of Agadir, Ministry of Health, Agadir, Morocco.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Izaabel</LastName>
<ForeName>El Hassan</ForeName>
<Initials>EH</Initials>
<AffiliationInfo><Affiliation>Laboratory of Cellular Biology and Molecular Genetics, Faculty of Sciences, Ibn Zohr University, Agadir, Morocco.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2019</Year>
<Month>11</Month>
<Day>18</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Genet Test Mol Biomarkers</MedlineTA>
<NlmUniqueID>101494210</NlmUniqueID>
<ISSNLinking>1945-0257</ISSNLinking>
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<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D016207">Cytokines</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C000630066">LTA protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D008233">Lymphotoxin-alpha</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014409">Tumor Necrosis Factor-alpha</NameOfSubstance>
</Chemical>
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<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000483" MajorTopicYN="N">Alleles</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016207" MajorTopicYN="N">Cytokines</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005787" MajorTopicYN="N">Gene Frequency</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020022" MajorTopicYN="N">Genetic Predisposition to Disease</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005838" MajorTopicYN="N">Genotype</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015810" MajorTopicYN="N">Linkage Disequilibrium</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008233" MajorTopicYN="N">Lymphotoxin-alpha</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009018" MajorTopicYN="N" Type="Geographic">Morocco</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020641" MajorTopicYN="N">Polymorphism, Single Nucleotide</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014409" MajorTopicYN="N">Tumor Necrosis Factor-alpha</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Moroccan population</Keyword>
<Keyword MajorTopicYN="N">polymorphism</Keyword>
<Keyword MajorTopicYN="N">tumor necrosis factor genes</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2019</Year>
<Month>11</Month>
<Day>19</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<PubMedPubDate PubStatus="medline"><Year>2020</Year>
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Genetic Distribution of the LTA +252 A>G and TNFA -308 G > A Polymorphisms in the Moroccan Population.

Genetic Distribution of the LTA +252 A>G and TNFA -308 G > A Polymorphisms in the Moroccan Population.

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